![]() I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as. I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. The title of the study is: intraoperative evoked potential recording for localization of deep brain stimulation electrodes. The IRBNET ID is 1585019-4 and is funded by CHOC neurology. The protocol, procedure and research use of data was approved by the institutional review board (#200330) of Children's Health Orange County (CHOC). Patients or parents of minor patients provided Health Insurance Portability and Accountability Act (HIPAA) authorization for the research use of protected health information and written informed consent for surgical procedures conforming to standard hospital practice, and for research use of electrophysiological data before the procedure. The details of the IRB/oversight body that provided approval or exemption for the research described are given below: I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. This study is funded by the Cerebral Palsy Alliance Research Foundation (PG02518), and CHOC Neurology. The authors have declared no competing interest. Further studies are necessary to confirm the feasibility of detecting differences between anatomic and non-anatomic pathways. ![]() The methodology described offers a tool for predicting the transmission of DBS through deep brain networks. Transfer function analysis was performed to compare the transmission of signals from external electrical stimulation, along orthodromic and antidromic pathways, with the transmission of intrinsic brain signals. To test this hypothesis, we acquired intrinsic brain signals and DBS EPs through depth electrodes in seven children with dystonia. We hypothesize that the pathways that transmit external electrical stimulation (DBS) include the pathways that transmit intrinsic neural signals, and are more likely to travel in the same direction as intrinsic signals. This study aims to examine and shed light on how electrical stimulation from DBS pulses is carried along neural pathways. An understanding of functional and structural connectivity in patients with movement disorders is critical for determining the mechanism of DBS. The availability of EP recordings during DBS provides an opportunity to investigate functional connectivity between deep brain regions. While the significance of these EPs for therapeutic outcomes is not known, it appears that the electrical effects of DBS have at least a partial modulatory effect on downstream targets. However, despite the similarity of DBS to the effects of lesions in early studies, recent work has shown that DBS can lead to robust evoked potentials (EP) not only at the stimulation site, but also in multiple distant brain regions. ![]() It is often assumed that the primary effect of DBS occurs at the site of stimulation, potentially blocking or distorting intrinsic abnormal signals. Deep brain stimulation (DBS) is used for targeted neuro-modulation in the treatment of patients with movement disorders.
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